Tells the epic story of the first contact, encounter, rapprochement, betrayal, and possible friendship that transcends life, between Karamakate, an Amazon Shaman, the last survivor of his tribe, and two scientists who, forty years apart, travel the Amazon in search of of a sacred plant that could cure his ills. Inspired by the diaries of the first explorers who traveled the Colombian Amazon, Theodor Koch-Grunberg and Richard Evan Schultes.